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CLOZARIL® (clozapine), an atypical antipsychotic drug, is a tricyclic dibenzodiazepine derivative, 8-chloro-11- (4-methyl-1-piperazinyl)-5H-dibenzo [b,e] [1,4] diazepine The structural formula is CLOZARIL is available in pale yellow tablets of 25 mg and 100 mg for oral administration Active Ingredient: clozapine --- ncbi nlm nih gov pmc articles PMC6481768clozapine and metoclopramide both increase antidopaminergic effects, including extrapyramidal symptoms and neuroleptic malignant syndrome Use Caution Monitor metronidazole will increase the level or effect of clozapine by affecting hepatic intestinal enzyme CYP3A4 metabolism Use Caution Monitor Clozapine (Clozaril) is used to treat schizophrenia It's an atypical antipsychotic, but it's not a first-choice medication for schizophrenia because it can cause many bothersome side effects, such as drowsiness and dizziness It can also cause your white blood cell (WBC) count to drop dangerously low and raise your risk for serious infections --- psychdb com meds antipsychotics second-gen-atypical 7-clozapineFor adults over 16 years of age, clozapine should be started at a very low dose, e g 12 5 mg once or twice a day On the second day, 25 mg to 50 mg is given, and, if well tolerated, the dose can be gradually increased in steps of 25 mg to 50 mg daily over 14 to 21 days up to 300 mg daily in divided doses --- goodrx com clozapine what-is--- medicine com drug clozapine hcpMean dose is ~300 mg daily; maximum total daily dose: 900 mg Dosage adjustment with concomitant therapy: Strong CYP1A2 inhibitors (eg, fluvoxamine, ciprofloxacin): Initiating clozapine with concomitant medication or adding a concomitant medication while taking clozapine: Use one-third of the clozapine dose Clozapine has been found to be an effective treatment in persons with schizophrenia resistant to treatment with other antipsychotic drugs In addition, clozapine is an effective treatment for schizophrenia accompanied by persistent suicidal or self-injurious behavior (See "Schizophrenia in adults: Maintenance therapy and side effect management" )--- drugs com dosage clozaril htmlDosing Information The starting dose is 12 5 mg once daily or twice daily The total daily dose can be increased in increments of 25 mg to 50 mg per day, if well-tolerated, to achieve a target dose of 300 mg to 450 mg per day (administered in divided doses) by the end of 2 weeks Subsequently, the dose can be increased once weekly or twice Clozaril is used to treat schizophrenia in adults after other treatments have failed Clozaril is available only from a certified pharmacy under a special program Clozaril is also used to reduce the risk of suicidal behavior in adults with schizophrenia or similar disorders Warnings Clozaril affects your immune system --- uptodate com schizophrenia-in-adults-guidelines-for-prescribing-cloza --- rxlist com clozaril-drug htmClozapine is a psychiatric medication and is the first atypical antipsychotic (also called second-generation antipsychotic) to be discovered It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics or who have been unable to tolerate other drugs due to extrapyramidal side effects --- drugs com clozaril htmlClozapine (Clozaril) Primer Clozapine (Trade name: Clozaril) is a an antipsychotic in the atypical antipsychotic class used in the treatment of schizophrenia, especially in patients who are resistant to other antipsychotics It is commonly referred to as a “last-line antipsychotic ” It is a low potency antipsychotic and highly anticholingeric, which gives it a very low incidence of en wikipedia org wiki Clozapinereference medscape com drug clozaril-versacloz-clozapine-342972
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